|
KMID : 0525720080130010006
|
|
Journal of Chitin and Chitosan
2008 Volume.13 No. 1 p.6 ~ p.8
|
|
|
Chitosan Oligomer as a Hopeful Adjuvant for H5n1 Influenza Vaccine
|
|
Hiep Le Ven
Thanh Mai Thi
Van Dang Thi Hong
Khanh Vo Thi Phuong
Dzung Nguyen Anh
|
|
|
Abstract
|
|
|
Effect of Chitosan oligomer (dp = 8-16) and other adjuvant such as: Aluminum phosphate (AlPO4) and Freund on immune
response of H5N1 influenza vaccine in Swiss mice has been investigated. The Swiss mice were twice vaccinated alternative 20 days with dose 0.1 ml/mouse. After 10, 20 and 30 days, the immune response of Swiss mice with H5N1 vaccine was detected. The result showed that after 20 days of the first vaccination, immune response of chitosan oligomer test and Freund was 100%, but Freund test reduced 80% after 30days of vaccination. Meanwhile, immune response of the control and AlPO4 test was very low, only 40%. The Effect of chitosan oligomer and the others on antibody titer has been also investigated. The result showed that the antibody titer of chitosan oligomer test was 60 HIU (Hemagglutination units), 70 HIUs after 10 and 20 days of the first vaccination, and increased up to 112 HIUs after 10 days of the second vaccination and the antibody titer of the chitosan oligomer test was higher than the others. Therefore, chitosan oligomer is a hopeful adjuvant for H5N1 influenza vaccine.
|
|
|
KEYWORD
|
|
|
Chitosan oligomer, Adjuvant, H5N1 influenza vaccine, Immune response, Antibody titer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|